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Bt菌亲友团中不断传出克癌消息

楼主:wannian 时间:2014-09-20 16:49:19 点击:688 回复:8
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  利用细菌芽孢杀癌,这是抗癌分子的一大发明。苏菌,Bacillus thuringiensis(Bt)的某些不具杀虫毒素的菌株,会制造抗癌蛋白,所谓Parasporin,又称84-HS-1-11蛋白。该蛋白在体外,对癌细胞有强大摧毁杀力。苏菌的户口来自厚壁菌门,Firmicutes。同门中,同样具有芽孢形成力的细菌如Clostridium(梭形) novyi,则更进一步,已经有在人体内杀伤癌细胞的战绩。厚壁门中还有菌种如乳酸杆菌,也时有传闻,具有抗癌本领。由于乳酸杆菌没有芽孢结构,这里暂且忽略不表。

  待续
楼主wannian 时间:2014-09-22 13:57:21
  Bacillus thuringiensis(Bt)和Clostridium(梭形) novyi是内生孢子菌的代表。什么是内生孢子,回忆三国演义中刘夫人在危急之际,将阿斗托付赵云一节,就好理解了。当细菌面临不利环境时,保存繁殖要件的微繁殖体就会在细菌内形成----历经几个小时。如果是厌氧菌如Clostridium(梭形) novyi,面临有氧环境时,就是危机,就要形成内孢。细菌内孢子保存了细菌繁殖的物质和能力,一逢适当的环境,孢子就可以重启繁殖发展。在孢子中,某些蛋白质也可以有存入,可以长期保存。例如,Bt的杀虫蛋白,就可以来自孢子。
作者 :春江沐雨 时间:2014-09-23 08:21:10
  zhuan fa
楼主wannian 时间:2014-09-23 13:49:47
  问大姐好!穿接引文,请先睹:
  CANCER
  Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses
  http://stm.sciencemag.org/content/6/249/249ra111.abstract
楼主wannian 时间:2014-09-23 13:52:20
  天才构思叹为观止。

  Abstract

  Species of Clostridium bacteria are notable for their ability to lyse tumor cells growing in hypoxic environments. We show that an attenuated strain of Clostridium novyi (C. novyi-NT) induces a microscopically precise, tumor-localized response in a rat orthotopic brain tumor model after intratumoral injection. It is well known, however, that experimental models often do not reliably predict the responses of human patients to therapeutic agents. We therefore used naturally occurring canine tumors as a translational bridge to human trials. Canine tumors are more like those of humans because they occur in animals with heterogeneous genetic backgrounds, are of host origin, and are due to spontaneous rather than engineered mutations. We found that intratumoral injection of C. novyi-NT spores was well tolerated in companion dogs bearing spontaneous solid tumors, with the most common toxicities being the expected symptoms associated with bacterial infections. Objective responses were observed in 6 of 16 dogs (37.5%), with three complete and three partial responses. On the basis of these encouraging results, we treated a human patient who had an advanced leiomyosarcoma with an intratumoral injection of C. novyi-NT spores. This treatment reduced the tumor within and surrounding the bone. Together, these results show that C. novyi-NT can precisely eradicate neoplastic tissues and suggest that further clinical trials of this agent in selected patients are warranted.
  Copyright ? 2014, American Association for the Advancement of Science
楼主wannian 时间:2014-09-24 19:34:59
  Clostridium novyi这款细菌,毒性原本很大。它正常情况下也存在于人肠之内。在有氧的条件下,它是非致病菌。但是,在有氧条件下,它会具有更多的产生内孢子的倾向。在组织缺氧条件下,它可以直接繁殖,其释放出的毒素可以引起组织坏疽。在缺氧条件下,其脱离母体的孢子也可以直接再繁殖。

  用于抗癌的Clostridium novyi,是经过减毒处理的菌株(C. novyi-NT)的孢子。科研人员直接将其减毒孢子经电脑控制注入肿瘤。进入缺氧的肿瘤组织的C. novyi-NT孢子,一面繁殖,一面摧毁肿瘤组织。但细菌蔓延到正常周围组织时,遇到有氧组织有氧环境,立即改恶从善,改邪归正,不再兴风作浪。

  在上述病例,病人肿瘤已经扩散。科研人员下一步,要将孢子直接输入血液,希望孢子自行寻找肿瘤扩散点,精确制导摧毁肿瘤。
  多少期望,多少等待,聚集在未来几天的实验上。
楼主wannian 时间:2014-09-27 13:33:49
  回到老苏菌。Bt细菌的基因,不仅出产抗虫毒素,而且出产对人类的抗癌毒素。对此,有引文可参看:http://cvi.asm.org/content/7/4/625.full?view=long&pmid=10882663(Parasporin, a Human Leukemic Cell-Recognizing Parasporal Protein of Bacillus thuringiensis)从标题中,我就看见了诸如人白血病细胞(T淋巴细胞白血病),孢子,Bt菌等主题词。产生抗白血病蛋白的菌株为B. thuringiensis serovar kurstaki(H3abc) ,这是一款在日本首先发现的不具有抗虫性能的Bt亚型。注意,虽然该毒素主要见于某苏菌亚型,但在所有的苏菌中,它都有基因成分及其表达,不过含量或低微而已。

  迄今为止,关于Parasporin抗癌的研究,未见有人体内试验。

  各种毒素五花八门,Bt家族很精彩。
楼主wannian 时间:2014-09-30 13:45:37
  C. novyi-NT,我心许的小细菌。我将密切追踪有关部门如研究所药厂等的动静。将来上天眷顾我一个“仙果”,就用这个小东西的孢子打发了,就这么定了。从理论上看,这玩意的孢子就是口服,也是可能的。
作者 :我碍你至 时间:2017-04-13 14:21:00
  任何微观世界,分子原子世界都有它们自己的生存方式,人类只能通过科技逐渐去尝试了解它们,我要有这么多亿的办晚会钱,一定给科学家不是伪专家们,让他们解放人类顽固疾病,让他们得到世界的尊重和重视

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